Lang Kerstin, Drell Theodore L, Zaenker Kurt S, Entschladen Frank
Institute of Immunology, Witten/Herdecke University, Witten, Germany.
Recent Pat Anticancer Drug Discov. 2006 Jan;1(1):69-80. doi: 10.2174/157489206775246511.
A leading cause of death, cancer remains the bane of modern society and one of the most challenging research fields. Cancer is initially a localized disease that can be often treated well at a very early stage. However the vast majority of cancer deaths result from a pernicious progression of the disease, the development of distant metastases. It must therefore be a pressing research goal to focus on the pharmacological prevention of metastasis development. This review summarizes the current understanding of the cellular and molecular mechanisms of metastasis development, and suggests possible approaches for its inhibition.
作为主要死因之一，癌症仍然是现代社会的祸根，也是最具挑战性的研究领域之一。癌症最初是一种局部疾病，在早期通常可以得到很好的治疗。然而，绝大多数癌症死亡是由疾病的恶性进展，即远处转移的发生所致。因此，专注于转移发生的药理学预防必然是一个紧迫的研究目标。本综述总结了目前对转移发生的细胞和分子机制的理解，并提出了可能的抑制方法。
