Bekers O, Beijnen J H, Tank M J, Bult A, Underberg W J
Department of Pharmaceutical Analysis, Faculty of Pharmacy, Utrecht University, The Netherlands.
J Pharm Biomed Anal. 1991;9(10-12):1055-60. doi: 10.1016/0731-7085(91)80044-a.
The effects of cyclodextrins on the chemical stability of several mitomycin antibiotics in an alkaline medium have been investigated. A stability-indicating high-performance liquid chromatographic method was used to determine the overall degradation rate constants. The influence of various parameters such as structural variations of the cyclodextrins and mitomycins, temperature and pH was studied. It appears that complexation is most favourable with gamma-cyclodextrin. All mitomycin-gamma-cyclodextrin complexes degrade at lower rates than those of the free drugs. Moreover, it was shown that gamma-cyclodextrin influences the equilibrium between mitomycin C and its zwitterion mesomer.
研究了环糊精对几种丝裂霉素抗生素在碱性介质中化学稳定性的影响。采用一种稳定性指示高效液相色谱法测定总体降解速率常数。研究了各种参数的影响，如环糊精和丝裂霉素的结构变化、温度和pH值。结果表明，γ-环糊精形成的络合物最为有利。所有丝裂霉素-γ-环糊精络合物的降解速率均低于游离药物。此外，研究还表明，γ-环糊精会影响丝裂霉素C与其两性离子异构体之间的平衡。
