2',3'-双脱氧肌苷（ddI）：其在水性介质中的化学稳定性及与环糊精的络合作用

2',3'-dideoxyinosine (ddI): its chemical stability and cyclodextrin complexation in aqueous media.

作者信息

Bekers O, Beijnen J H, Tank M J, Burger D M, Meenhorst P L, Lombarts A J, Underberg W J

机构信息

Department of Clinical Chemistry, Leyenburg Hospital, The Hague, The Netherlands.

出版信息

J Pharm Biomed Anal. 1993 Jun;11(6):489-93. doi: 10.1016/0731-7085(93)80162-t.

DOI:10.1016/0731-7085(93)80162-t

PMID:8399520

Abstract

The chemical stability of 2',3'-dideoxyinosine has been studied over a wide pH range (0-12). A stability-indicating HPLC method was used to separate the degradation product from the parent drug. The effects of temperature, ionic strength and buffer components on the degradation kinetics were investigated. Furthermore, the influence of some cyclodextrins (alpha-, beta-, HP-beta-, DM-beta- and gamma-cyclodextrin) on the drug stability have been studied.

摘要

已在较宽的pH范围（0 - 12）内研究了2',3'-双脱氧肌苷的化学稳定性。采用一种稳定性指示高效液相色谱法将降解产物与母体药物分离。研究了温度、离子强度和缓冲液成分对降解动力学的影响。此外，还研究了一些环糊精（α-、β-、羟丙基-β-、二甲基-β-和γ-环糊精）对药物稳定性的影响。