Gjesdal Clara G, Halse Johan I, Eide Geir Egil, Brun Johan G, Tell Grethe S
Section for Epidemiology and Medical Statistics, Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway.
Maturitas. 2008 Feb 20;59(2):191-200. doi: 10.1016/j.maturitas.2007.11.002. Epub 2008 Jan 24.
To examine the relationship between soft tissue composition and bone mineral density (BMD) of the hip and whether these relationships differ by gender and age.
Femoral neck BMD and total body soft tissue composition were measured by dual X-ray absorptiometry in a population-based sample of 5205 men and women 47-50 and 71-75 years old. Analysis of covariance was used to explore possible modifying effects of sex and gender on the impact of fat and lean mass on BMD.
The difference in BMD per kilo lean mass (LM) was larger than the difference per kilo fat mass (FM). The effect of FM on BMD was significantly greater among women than among men. In multivariate adjusted analyses, 10kg increase in LM was associated with a 0.083 (95% confidence interval [CI]: 0.075, 0.092)g/cm(2) increase in BMD. A 10kg increase in FM was associated with 0.013 (0.007, 0.019)g/cm(2) increase in BMD among men and 0.021 (0.017, 0.026)g/cm(2) among women. There was indication of a steeper dose-response relationship at lower levels of FM among women.
Compared to FM, LM was generally more strongly related to BMD of the femoral neck in middle-aged and elderly men and women. FM was a significantly stronger predictor of BMD among women than among men, particularly at lower levels of FM.
研究软组织成分与髋部骨密度（BMD）之间的关系，以及这些关系在性别和年龄上是否存在差异。
采用双能X线吸收法测量了5205名年龄在47 - 50岁和71 - 75岁的男性和女性基于人群样本的股骨颈骨密度和全身软组织成分。使用协方差分析来探讨性别对脂肪量和瘦体重对骨密度影响的可能修正作用。
每千克瘦体重（LM）的骨密度差异大于每千克脂肪量（FM）的差异。女性中FM对骨密度的影响显著大于男性。在多变量调整分析中，LM增加10kg与骨密度增加0.083（95%置信区间[CI]：0.075，0.092）g/cm²相关。FM增加10kg在男性中与骨密度增加0.013（0.007，0.019）g/cm²相关，在女性中与骨密度增加0.021（0.017，0.026）g/cm²相关。有迹象表明女性在较低FM水平下剂量反应关系更陡峭。
与FM相比，LM通常与中老年男性和女性的股骨颈骨密度关系更强。FM在女性中是比男性更强的骨密度预测指标，尤其是在较低FM水平时。
