Health Care Center, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea.
Bone. 2012 Apr;50(4):1006-11. doi: 10.1016/j.bone.2012.01.015. Epub 2012 Jan 28.
The potential beneficial effects of increased body weight on bone mineral density (BMD) conflict with the adverse effects of obesity on various health outcomes, necessitating more specific evaluations of the association between each body component and BMD. In the present study, we evaluated associations of lean mass (LM) and fat mass (FM) with BMD in a Korean sample consisting of a total of 1782 men and women whose mean (standard deviation) age was 43.2 (12.6) years. They were selected from the Healthy Twin Study, a nationwide Korean twin and family study. BMD, FM and LM were measured using dual-energy X-ray absorptiometry. Quantitative genetic analysis and linear mixed analysis were performed with respect to familial relationships and a wide range of probable covariates. Linear mixed analysis revealed that BMD was positively associated with both FM and LM at each region of BMD measurement (whole body, spine, arms, and legs) in men, premenopausal women, and postmenopausal women. However, the association with BMD was stronger for LM than FM. Both LM and FM had positive genetic correlations with BMD at each region, although the correlation with BMD tended to be stronger for LM than FM. Together, these findings suggest that increased LM, rather than FM, is more beneficial for BMD in the Korean population and warrants further study of the common genetic determinants of BMD and body composition.
体重增加对骨密度（BMD）的潜在有益影响与肥胖对各种健康结果的不利影响相冲突，因此需要更具体地评估每个身体成分与 BMD 的关系。在本研究中，我们评估了韩国样本中瘦体重（LM）和脂肪量（FM）与 BMD 的相关性，该样本共包括 1782 名年龄均为 43.2（12.6）岁的男性和女性。他们是从健康双胞胎研究中选择的，这是一项全国性的韩国双胞胎和家庭研究。使用双能 X 射线吸收法测量 BMD、FM 和 LM。针对家族关系和广泛的可能协变量进行了定量遗传分析和线性混合分析。线性混合分析显示，在男性、绝经前女性和绝经后女性的 BMD 测量的每个部位（全身、脊柱、手臂和腿部），BMD 与 FM 和 LM 均呈正相关。然而，与 BMD 的相关性，LM 强于 FM。LM 和 FM 与 BMD 在每个部位均具有正的遗传相关性，尽管与 BMD 的相关性，LM 强于 FM。综上所述，这些发现表明，在韩国人群中，增加的 LM 而不是 FM 更有利于 BMD，这需要进一步研究 BMD 和身体成分的常见遗传决定因素。
