Kaur Maninder, Kaur Raminder
Department of Anthropology, Panjab University, Chandigarh, India.
J Menopausal Med. 2025 Apr;31(1):12-20. doi: 10.6118/jmm.24021.
This cross-sectional study assessed the association between body composition characteristics and bone mineral density (BMD) across different menopausal transition stages.
In total, 320 rural women aged 45-60 years were recruited. Body composition and BMD at different skeletal sites were evaluated by dual energy X-ray absorptiometry.
The BMD and bone mineral content of the entire hip, lumbar region, and left arm significantly decreased across most of the menopausal transition stages, which was confirmed by Tukey post hoc analysis. Multiple linear regression analysis revealed that BMD at the hip, lumbar region, and left arm were strongly and positively associated with weight. However, BMD was negatively associated with % total body fat (TBF) across all the four menopausal stages except for lumbar BMD at the late postmenopausal stage (Model 1). Lean mass was positively and significantly associated with BMD at all the skeletal sites evaluated except for some fluctuations in lumbar BMD (Model 2). Furthermore, waist circumference was significantly associated with BMD in the late postmenopausal stage (Model 3) .
Weight and lean mass are significant predictors of BMD during the menopausal transition and beyond. Furthermore, %TBF may be a negative indicator of BMD.
本横断面研究评估了不同绝经过渡阶段身体成分特征与骨密度（BMD）之间的关联。
共招募了320名年龄在45至60岁之间的农村女性。通过双能X线吸收法评估不同骨骼部位的身体成分和骨密度。
经Tukey事后分析证实，在大多数绝经过渡阶段，整个髋部、腰椎区域和左臂的骨密度和骨矿物质含量显著下降。多元线性回归分析显示，髋部、腰椎区域和左臂的骨密度与体重呈强正相关。然而，除绝经后期腰椎骨密度外，在所有四个绝经阶段，骨密度与全身脂肪百分比（TBF）呈负相关（模型1）。除腰椎骨密度有一些波动外，瘦体重与所有评估骨骼部位的骨密度呈显著正相关（模型2）。此外，腰围在绝经后期与骨密度显著相关（模型3）。
体重和瘦体重是绝经过渡期间及之后骨密度的重要预测指标。此外，TBF百分比可能是骨密度的一个负指标。
