George Washington Univ., Washington, DC.
IEEE Trans Med Imaging. 1991;10(3):413-25. doi: 10.1109/42.97592.
The authors present an efficient algorithm and the results of its application in simulating the three-dimensional (3-D) projection data resulting from a 3-D distribution of radioactivity. The algorithm was applied to a series of geometrical mathematical phantoms and to a realistic mathematical brain phantom. The authors simulated the projection data from a multidetector single-photon emission computed tomography (SPECT) system with point focusing collimators. The simulated projection data were then reconstructed using the manufacturer's software. The objects simulated included simple geometrical solids such as spheres and sheets, as well as the distribution of muscarinic cholinergic receptors in a realistic brain slice. Spheres were chosen as a model for brain structures such as caudate nucleus, thalamus, and cerebellum; sheets were selected as representing lateral cortical gray matter regions. The results of these simulations indicate the existence of significant qualitative and quantitative artifacts in reconstructed human brain images.
作者提出了一种有效的算法，并展示了其在模拟放射性三维分布的三维投影数据中的应用结果。该算法应用于一系列几何数学体模和一个现实的数学脑体模。作者模拟了具有点聚焦准直器的多探测器单光子发射计算机断层扫描（SPECT）系统的投影数据。然后使用制造商的软件重建模拟的投影数据。模拟的对象包括简单的几何固体，如球体和薄片，以及真实脑切片中毒蕈碱型乙酰胆碱受体的分布。球体被选为尾状核、丘脑和小脑等脑结构的模型；薄片被选为代表外侧皮质灰质区域的模型。这些模拟的结果表明，在重建的人脑图像中存在显著的定性和定量伪影。
