Maron David J, Fry Robert D
Division of Colon and Rectal Surgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4283, USA.
Am J Ther. 2008 Jan-Feb;15(1):59-65. doi: 10.1097/MJT.0b013e31804c6f37.
Postoperative ileus after gastrointestinal surgery results from many factors, including the effects of surgical trauma, anesthetic agents, hyperactivity of the sympathetic nervous system, local inflammatory reactions, and the use of opioids in the postoperative period. Postoperative ileus can lead to potential complications and may prolong patients' hospitalization, thereby leading to an increase in healthcare costs. There have been recent efforts to improve the understanding of the pathogenesis of postoperative ileus and to develop new treatments to prevent or minimize its occurrence. Here, we present a review of the factors related to the development of postoperative ileus and new therapies directed at its prevention.
胃肠道手术后的术后肠梗阻由多种因素引起，包括手术创伤的影响、麻醉剂、交感神经系统功能亢进、局部炎症反应以及术后使用阿片类药物。术后肠梗阻可导致潜在并发症，并可能延长患者住院时间，从而导致医疗费用增加。最近人们一直在努力加深对术后肠梗阻发病机制的理解，并开发新的治疗方法以预防或尽量减少其发生。在此，我们对与术后肠梗阻发生相关的因素以及针对其预防的新疗法进行综述。
