Giannoudis Peter V, Psarakis Spyridon, Kanakaris Nikolaos K, Pape Hans-Christoph
Academic Dept of Trauma & Orthopaedics, Leeds Teaching Hospitals, University of Leeds, UK.
Injury. 2007 Sep;38 Suppl 4:S43-8. doi: 10.1016/s0020-1383(08)70008-1.
Post-trauma and post-partum pelvic ring instability and non-union are treated operatively with internal fixation and a biological enhancement stimulus. The application of BMP-7 in nine cases of persistent instability located at the anterior or the posterior elements of the pelvic girdle is prospectively evaluated for its safety and efficacy. Fusion was achieved in 89% of the patients. 78% of the patients reported excellent or good subjective functional results at a median follow up period of 12 months (range 12-27). The utilisation of BMP-7 was not associated with any adverse reactions or complications. Encouraging results of biological enhancement of bone healing with BMP-7 at the clinical setting of traumatic pelvic ring non-unions and postpartum instability were achieved. The implantation of BMP-7 in pelvic reconstruction procedures adds another alternative to the treatment methods of contemporary orthopaedics.
创伤后和产后骨盆环不稳定及骨不连采用内固定和生物增强刺激进行手术治疗。前瞻性评估了BMP - 7在9例位于骨盆带前部或后部的持续性不稳定病例中的应用安全性和有效性。89%的患者实现了融合。在中位随访期12个月（范围12 - 27个月）时，78%的患者报告主观功能结果为优或良。使用BMP - 7未出现任何不良反应或并发症。在创伤性骨盆环骨不连和产后不稳定的临床环境中，BMP - 7对骨愈合的生物增强取得了令人鼓舞的结果。在骨盆重建手术中植入BMP - 7为当代骨科治疗方法增添了另一种选择。
