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骨盆脆性骨折——当前的认识与待解决的问题

Fragility Fractures of the Pelvis-Current Understanding and Open Questions.

作者信息

Gordon Amber, Saracco Michela, Giannoudis Peter V, Kanakaris Nikolaos K

机构信息

Leeds Major Trauma Centre, Leeds Teaching Hospitals, Leeds LS1 3EX, UK.

Academic Department of Trauma and Orthopaedics, University of Leeds, Leeds LS2 9JT, UK.

出版信息

J Clin Med. 2025 Jul 18;14(14):5122. doi: 10.3390/jcm14145122.

Abstract

Fragility fractures of the pelvis (FFPs) are common in elderly patients, particularly those with osteoporosis. FFPs can be associated with high mortality, morbidity, and functional decline. Known risk factors include being over 80 years old and delays in surgical intervention when this is required. While the role of surgery in FFPs remains less defined than in proximal femoral fractures in the elderly, studies indicate that surgical fixation offers improved survival and functional outcomes. Similarly, the choice of fixation method, whether posterior or anterior, and their combinations, vary between clinicians. It depends on the fracture type and patient-specific factors, such as bone quality and comorbidities, as well as the surgeon's experience and the availability of resources. Additionally, orthobiologic adjuncts such as cement augmentation and sacroplasty can enhance the stability of an osteoporotic fracture during surgical intervention. Furthermore, medical treatments for osteoporosis, especially the use of teriparatide, have demonstrated beneficial effects in reducing fractures and promoting healing of the FFPs. Return to pre-injury activities is often limited, with independence rates remaining low at mid-term follow-up. Factors that influence clinical outcomes include fracture type, with Type III and IV fractures generally leading to poorer outcomes, and patient age, functional reserve, and comorbidities. The present tutorial aims to summarise the relevant evidence on all aspects of FFPs, inform an updated management strategy, and provide a template of the reconstruction ladder referring to the most available surgical techniques and treatment methods. Further research, based on large-scale studies, is needed to address the open questions described in this manuscript and refine surgical techniques, as well as determine optimal treatment pathways for this vulnerable patient population.

摘要

骨盆脆性骨折(FFPs)在老年患者中很常见,尤其是患有骨质疏松症的患者。FFPs可能与高死亡率、发病率和功能衰退相关。已知的风险因素包括年龄超过80岁以及在需要手术干预时的延迟。虽然手术在FFPs中的作用仍不如在老年股骨近端骨折中明确,但研究表明手术固定可提高生存率和功能结局。同样,固定方法的选择,无论是后路还是前路,以及它们的组合,在临床医生之间各不相同。这取决于骨折类型和患者特定因素,如骨质质量和合并症,以及外科医生的经验和资源可用性。此外,诸如骨水泥强化和骶骨成形术等骨科生物辅助手段可在手术干预期间增强骨质疏松性骨折的稳定性。此外,骨质疏松症的药物治疗,尤其是特立帕肽的使用,已显示出在减少骨折和促进FFPs愈合方面的有益效果。恢复到伤前活动通常受到限制,中期随访时的独立率仍然较低。影响临床结局的因素包括骨折类型,III型和IV型骨折通常导致较差的结局,以及患者年龄、功能储备和合并症。本教程旨在总结关于FFPs各方面的相关证据,为更新的管理策略提供信息,并提供一个重建阶梯模板,参考最常用的手术技术和治疗方法。需要基于大规模研究的进一步研究来解决本手稿中描述的未解决问题,完善手术技术,并确定针对这一脆弱患者群体的最佳治疗途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/053a/12295175/5219d332247d/jcm-14-05122-g001.jpg

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