Taylor J, Chao M, Hsieh S Y, Ryu W S
Fox Chase Cancer Center, Philadelphia, PA 19111.
J Hepatol. 1991;13 Suppl 4:S119-20. doi: 10.1016/0168-8278(91)90041-9.
The delta antigen is the only known protein encoded by hepatitis delta virus (HDV). The predicted protein is 195 amino acids in length, but for reasons that are not yet clear, there occurs during the replication of the HDV genome, a specific base change in the termination codon of this open reading frame. This leads to the synthesis of a form of the delta antigen that is 19 amino acids longer, with a total length of 214 amino acids. Studies are described which relate to the roles of these two forms of the delta antigen in genome replication and subsequent particle assembly.
δ抗原是丁型肝炎病毒（HDV）编码的唯一已知蛋白质。预测的蛋白质长度为195个氨基酸，但由于尚不清楚的原因，在HDV基因组复制过程中，该开放阅读框的终止密码子出现特定碱基变化。这导致合成一种长19个氨基酸的δ抗原形式，总长度为214个氨基酸。本文描述了有关这两种形式的δ抗原在基因组复制和随后的病毒颗粒组装中的作用的研究。
