Luo G X, Chao M, Hsieh S Y, Sureau C, Nishikura K, Taylor J
Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111.
J Virol. 1990 Mar;64(3):1021-7. doi: 10.1128/JVI.64.3.1021-1027.1990.
Three independent lines of evidence showed that when an infectious clone of hepatitis delta virus of known sequence was used to initiate genome replication, up to 41% of the genomes were specifically mutated in the amber termination codon (UAG to UGG) for the open reading frame of the delta antigen, thereby increasing the length of the predicted protein from 195 to 214 amino acids. This change was detected only on molecules that participated in RNA-directed RNA synthesis.
三条独立的证据表明，当使用已知序列的丁型肝炎病毒感染性克隆启动基因组复制时，高达41%的基因组在δ抗原开放阅读框的琥珀色终止密码子（UAG突变为UGG）处发生特异性突变，从而使预测蛋白质的长度从195个氨基酸增加到214个氨基酸。这种变化仅在参与RNA指导的RNA合成的分子上被检测到。
