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超肥胖患者手辅助腹腔镜胃旁路手术的结果

Outcome of hand-assisted laparoscopic gastric bypass in super obese patients.

作者信息

Hamed Osama, Kerlakian George, Engel Amy, Bollmer Cyndy

机构信息

Department of Surgery, Good Samaritan Hospital, Cincinnati, Ohio 45220, USA.

出版信息

Surg Obes Relat Dis. 2008 Sep-Oct;4(5):618-24. doi: 10.1016/j.soard.2007.11.001. Epub 2008 Jan 28.

Abstract

BACKGROUND

The optimal surgical treatment for super obese patients (body mass index [BMI] >or=50 kg/m2) has been a challenge and debate for most bariatric surgeons. To compare the outcomes of hand-assisted laparoscopic Roux-en-Y gastric bypass (HALGB) in super obese patients (BMI >or=50 kg/m2) to morbidly obese patients (BMI <50 kg/m2).

METHODS

A total of 295 patients who underwent HALGB from October 2003 to December 2005 were studied. These patients included 177 with a BMI of <or=49 kg/m2 (morbidly obese) and 118 with a BMI of >or=50 kg/m2 (super-obese). The patient demographics, complications, and outcomes were examined. Additionally, the 12-month postoperative outcomes included the percentage of excess weight loss and improvement of co-morbidities.

RESULTS

The patient age and gender were similar between the 2 groups. The super-obese patients had significantly more co-morbidities and required a greater number of medications. A significant difference was found in 3 early postoperative complications, with super-obese patients experiencing more wound infections (P = .039), nausea/vomiting (P = .003), and pulmonary failure (P = .010). Logistic regression analysis found, after controlling for significant risk factors, that the difference in the incidence of nausea/vomiting was still significant (odds ratio 14.33, 95% confidence interval 1.73-118.60, P = .01). Morbidly obese patients had a significantly greater percentage of excess weight loss at 12 months postoperatively compared with the super-obese patients (80% versus 55%, respectively, P <.001).

CONCLUSION

HALGB is a safe and effective procedure in the super obese but with less favorable outcomes compared with those for morbidly obese patients regarding the percentage of excess weight loss.

摘要

背景

对于大多数减肥外科医生而言,超级肥胖患者(体重指数[BMI]≥50kg/m²)的最佳手术治疗一直是一项挑战且存在争议。比较超级肥胖患者(BMI≥50kg/m²)与病态肥胖患者(BMI<50kg/m²)接受手辅助腹腔镜Roux-en-Y胃旁路术(HALGB)的效果。

方法

对2003年10月至2005年12月期间接受HALGB的295例患者进行研究。这些患者包括177例BMI≤49kg/m²(病态肥胖)和118例BMI≥50kg/m²(超级肥胖)。对患者的人口统计学特征、并发症及治疗效果进行检查。此外,术后12个月的结果包括超重减轻百分比及合并症的改善情况。

结果

两组患者的年龄和性别相似。超级肥胖患者的合并症明显更多,需要更多药物治疗。术后早期3种并发症存在显著差异,超级肥胖患者出现更多伤口感染(P = 0.039)、恶心/呕吐(P = 0.003)和肺功能衰竭(P = 0.010)。逻辑回归分析发现,在控制显著风险因素后,恶心/呕吐发生率的差异仍然显著(比值比14.33,95%置信区间1.73 - 118.60,P = 0.01)。病态肥胖患者术后12个月的超重减轻百分比明显高于超级肥胖患者(分别为80%和55%,P<0.001)。

结论

HALGB对超级肥胖患者是一种安全有效的手术,但在超重减轻百分比方面,与病态肥胖患者相比效果欠佳。

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