Hamed Osama, Kerlakian George, Engel Amy, Bollmer Cyndy
Department of Surgery, Good Samaritan Hospital, Cincinnati, Ohio 45220, USA.
Surg Obes Relat Dis. 2008 Sep-Oct;4(5):618-24. doi: 10.1016/j.soard.2007.11.001. Epub 2008 Jan 28.
The optimal surgical treatment for super obese patients (body mass index [BMI] >or=50 kg/m2) has been a challenge and debate for most bariatric surgeons. To compare the outcomes of hand-assisted laparoscopic Roux-en-Y gastric bypass (HALGB) in super obese patients (BMI >or=50 kg/m2) to morbidly obese patients (BMI <50 kg/m2).
A total of 295 patients who underwent HALGB from October 2003 to December 2005 were studied. These patients included 177 with a BMI of <or=49 kg/m2 (morbidly obese) and 118 with a BMI of >or=50 kg/m2 (super-obese). The patient demographics, complications, and outcomes were examined. Additionally, the 12-month postoperative outcomes included the percentage of excess weight loss and improvement of co-morbidities.
The patient age and gender were similar between the 2 groups. The super-obese patients had significantly more co-morbidities and required a greater number of medications. A significant difference was found in 3 early postoperative complications, with super-obese patients experiencing more wound infections (P = .039), nausea/vomiting (P = .003), and pulmonary failure (P = .010). Logistic regression analysis found, after controlling for significant risk factors, that the difference in the incidence of nausea/vomiting was still significant (odds ratio 14.33, 95% confidence interval 1.73-118.60, P = .01). Morbidly obese patients had a significantly greater percentage of excess weight loss at 12 months postoperatively compared with the super-obese patients (80% versus 55%, respectively, P <.001).
HALGB is a safe and effective procedure in the super obese but with less favorable outcomes compared with those for morbidly obese patients regarding the percentage of excess weight loss.
对于大多数减肥外科医生而言,超级肥胖患者(体重指数[BMI]≥50kg/m²)的最佳手术治疗一直是一项挑战且存在争议。比较超级肥胖患者(BMI≥50kg/m²)与病态肥胖患者(BMI<50kg/m²)接受手辅助腹腔镜Roux-en-Y胃旁路术(HALGB)的效果。
对2003年10月至2005年12月期间接受HALGB的295例患者进行研究。这些患者包括177例BMI≤49kg/m²(病态肥胖)和118例BMI≥50kg/m²(超级肥胖)。对患者的人口统计学特征、并发症及治疗效果进行检查。此外,术后12个月的结果包括超重减轻百分比及合并症的改善情况。
两组患者的年龄和性别相似。超级肥胖患者的合并症明显更多,需要更多药物治疗。术后早期3种并发症存在显著差异,超级肥胖患者出现更多伤口感染(P = 0.039)、恶心/呕吐(P = 0.003)和肺功能衰竭(P = 0.010)。逻辑回归分析发现,在控制显著风险因素后,恶心/呕吐发生率的差异仍然显著(比值比14.33,95%置信区间1.73 - 118.60,P = 0.01)。病态肥胖患者术后12个月的超重减轻百分比明显高于超级肥胖患者(分别为80%和55%,P<0.001)。
HALGB对超级肥胖患者是一种安全有效的手术,但在超重减轻百分比方面,与病态肥胖患者相比效果欠佳。