Menif Olfa, Omar Souheil, Feki Moncef, Kaabachi Naziha
Laboratoire de biochimie, Hôpital la Rabta de Tunis, Tunisie.
Ann Biol Clin (Paris). 2008 Jan-Feb;66(1):43-51. doi: 10.1684/abc.2008.0190.
Pregnancy is associated with physiological changes in thyroid function that may result in thyroid insufficiency, especially in presence of autoimmunity or iodine deficiency. Gestational hypothyroidism has been associated with adverse health outcomes for both the mother and child, including increased miscarriage risk and delayed neuropsychological development in neonate and child. The severity of such complications mainly depends on the precocity and the adequacy of L-thyroxin treatment. There is no consensus regarding systematic thyroid function testing in pregnant women. But, the majority of authors are favorable for systematic screening, especially in iodine deficient or marginally sufficient areas. However, when systematic screening could not be performed for economic reasons, physicians should achieve aggressive case finding for thyroid disease during pregnancy.
妊娠与甲状腺功能的生理变化相关,这可能导致甲状腺功能不足,尤其是在存在自身免疫或碘缺乏的情况下。妊娠期甲状腺功能减退与母婴不良健康结局相关,包括流产风险增加以及新生儿和儿童神经心理发育迟缓。此类并发症的严重程度主要取决于左甲状腺素治疗的及时性和充分性。对于孕妇进行系统的甲状腺功能检测尚无共识。但是,大多数作者赞成进行系统筛查,尤其是在碘缺乏或碘摄入略足的地区。然而,当由于经济原因无法进行系统筛查时,医生应在孕期积极发现甲状腺疾病病例。