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[实验室在一名2岁女童胰岛素给药所致低血糖症诊断中的作用]

[Contribution of the laboratory in hypoglycemia diagnosis induced by insulin administration in a 2-year-old girl].

作者信息

Dejoie T, Ramos E, Baron S, Bach-Ngohou K, Masson D

机构信息

Service de biochimie, Unité d'hormonologie et de RIA, CHU Hôtel Dieu, Nantes.

出版信息

Ann Biol Clin (Paris). 2008 Jan-Feb;66(1):82-6. doi: 10.1684/abc.2007.0182.

Abstract

We report the case of a 2 year-old child presented to the emergency department following a seizure. The child was hypotonic and examination was unremarkable but laboratory tests confirmed a severe hypoglycaemia. The insulin level, inappropriately high for the glycemia and the peptide C undetectable suggested exogenous hyperinsulinism. We conclude that the hypoglycaemia was likely the result of Munchhausen syndrome by proxy. The specificity of two immunoassays used (Elecsys Roche and IRMA CisBio) for the synthetic analogues of insulin explains the discrepancy between the insulin levels obtained but was crucially useful to the approach of the cause of the hypoglycaemia.

摘要

我们报告了一名2岁儿童在癫痫发作后被送往急诊科的病例。该儿童肌张力减退,体格检查无异常,但实验室检查证实存在严重低血糖。胰岛素水平相对于血糖水平而言过高,且未检测到C肽,提示外源性高胰岛素血症。我们得出结论,低血糖可能是代理型孟乔森综合征的结果。所使用的两种免疫测定法(罗氏电化学发光免疫分析法和希思生物免疫放射分析法)对胰岛素合成类似物的特异性解释了所测得的胰岛素水平之间的差异,但对查明低血糖病因至关重要。

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