1型下肢复杂性区域疼痛综合征的管理：经皮射频热凝腰交感神经切除术与酚甘油腰交感神经溶解术的评估——一项前瞻性研究
Management of lower limb complex regional pain syndrome type 1: an evaluation of percutaneous radiofrequency thermal lumbar sympathectomy versus phenol lumbar sympathetic neurolysis--a pilot study.
作者信息
Manjunath Prashanth S, Jayalakshmi T S, Dureja G P, Prevost A Toby
机构信息
Department of Anesthesiology, University of Miami-Jackson Memorial Hospital, Miami, FL, USA.
出版信息
Anesth Analg. 2008 Feb;106(2):647-9, table of contents. doi: 10.1213/01.ane.0000298285.39480.28.
BACKGROUND
Complex regional pain syndrome type 1 can be difficult to treat. The purpose of this study was to compare the safety and efficacy of two therapeutic options: percutaneous radiofrequency thermal lumbar sympathectomy and lumbar sympathetic neurolysis.
METHODS
We randomized 20 patients to receive percutaneous radiofrequency lumbar sympathectomy or lumbar sympathetic neurolysis with phenol 7% in lower limb complex regional pain syndrome type 1. The study end points were pain relief and side effects.
RESULTS
Within each group, there were statistically significant reductions from baseline in various pain scores after the procedure. However, there was no statistically significant difference in mean pain scores between the groups.
CONCLUSIONS
Based on this pilot study, radiofrequency lumbar sympathectomy may be comparable to phenol lumbar sympathectomy. A larger trial is required to confirm these findings.
背景
1型复杂性区域疼痛综合征可能难以治疗。本研究的目的是比较两种治疗方案的安全性和有效性：经皮射频热凝腰交感神经切除术和腰交感神经酚阻滞术。
方法
我们将20例1型下肢复杂性区域疼痛综合征患者随机分为两组，分别接受经皮射频腰交感神经切除术或7%苯酚腰交感神经阻滞术。研究终点为疼痛缓解情况和副作用。
结果
每组患者术后各种疼痛评分与基线相比均有统计学意义的降低。然而，两组间平均疼痛评分无统计学意义上的差异。
结论
基于这项初步研究，射频腰交感神经切除术可能与酚性腰交感神经切除术效果相当。需要进行更大规模的试验来证实这些发现。
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