Wang Xu, Yang Lily, Chen Zhuo Georgia, Shin Dong M
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
CA Cancer J Clin. 2008 Mar-Apr;58(2):97-110. doi: 10.3322/CA.2007.0003. Epub 2008 Jan 28.
Recent developments in nanotechnology have provided researchers with new tools for cancer imaging and treatment. This technology has enabled the development of nanoscale devices that can be conjugated with several functional molecules simultaneously, including tumor-specific ligands, antibodies, anticancer drugs, and imaging probes. Since these nanodevices are 100 to 1,000-fold smaller than cancer cells, they can be easily transferred through leaky blood vessels and interact with targeted tumor-specific proteins both on the surface of and inside cancer cells. Therefore, their application as cancer cell-specific delivery vehicles will be a significant addition to the currently available armory for cancer therapeutics and imaging.
纳米技术的最新进展为研究人员提供了用于癌症成像和治疗的新工具。这项技术推动了纳米级装置的发展,这些装置可以同时与多种功能分子结合,包括肿瘤特异性配体、抗体、抗癌药物和成像探针。由于这些纳米装置比癌细胞小100到1000倍,它们可以很容易地通过渗漏的血管转移,并与癌细胞表面和内部的靶向肿瘤特异性蛋白质相互作用。因此,它们作为癌细胞特异性递送载体的应用将是目前可用的癌症治疗和成像手段的一个重要补充。