Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, Telangana, India.
Division of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute, Lucknow, 226031, U.P., India.
AAPS PharmSciTech. 2024 Nov 5;25(8):265. doi: 10.1208/s12249-024-02977-6.
Albumin is a nature-derived, versatile protein carrier, that has been explored extensively by researchers for anticancer drug delivery due to its role in enhancing drug stability, solubility, circulation time, targeting capabilities, and overall therapeutic efficacy. Albumin nanoparticles possess inherent biocompatibility, biodegradability, and passive tumor-targeting ability due to the enhanced permeability and retention effect. However, non-specific accumulation of cytotoxic agents in healthy tissues remains a challenge. In this paper, the functionalization of albumin nanoparticles using various biomolecules including antibodies, nucleic acids, proteins and peptides, vitamins, chondroitin sulfate, hyaluronic acid, and lactobionic acid have been discussed which enables specific recognition and binding to cancer cells. Furthermore, we highlight the supremacy of such a targeted approach in tumor-specific drug delivery, minimization of off-target effects, potential improvement in therapeutic efficacy, cellular internalization, reduced side effects, and better clinical outcomes. This review centers on how they have revolutionized the field of biomedical research and tuned into an excellent targeted approach. In conclusion, this review highlights in detail the role of albumin as a nanocarrier for tumor-targeted delivery using biomolecules as ligands.
白蛋白是一种天然来源的多功能蛋白质载体，由于其在增强药物稳定性、溶解度、循环时间、靶向能力和整体治疗效果方面的作用，已被研究人员广泛探索用于抗癌药物输送。白蛋白纳米粒由于具有增强的通透性和保留效应，具有固有生物相容性、可生物降解性和被动肿瘤靶向能力。然而，细胞毒性药物在健康组织中的非特异性积累仍然是一个挑战。本文讨论了使用各种生物分子（包括抗体、核酸、蛋白质和肽、维生素、硫酸软骨素、透明质酸和乳糖酸）对白蛋白纳米粒进行功能化，使它们能够特异性识别和结合癌细胞。此外，我们强调了这种靶向方法在肿瘤特异性药物输送、最小化脱靶效应、提高治疗效果、细胞内化、减少副作用和改善临床结果方面的优势。本综述重点介绍了它们如何彻底改变了生物医学研究领域，并成为一种出色的靶向方法。总之，本综述详细说明了白蛋白作为生物分子作为配体的肿瘤靶向递药的纳米载体的作用。
