Muteeb Ghazala, El-Morsy Manar T, Abo-Taleb Mustafa Ali, Mohamed Salma K, Khafaga Doaa S R
Department of Nursing, College of Applied Medical Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Bio-Nanotechnology Department, Faculty of Nanotechnology, Cairo University, Giza 12613, Egypt.
Pharmaceutics. 2025 May 20;17(5):673. doi: 10.3390/pharmaceutics17050673.
Hepatocellular carcinoma (HCC) is an aggressive and prevalent liver cancer with a poor prognosis. Nanotechnology combined with natural products has emerged as a promising strategy to enhance HCC treatment efficacy. This review assesses the current literature on the application of nanotechnology in delivering natural products for HCC therapy. A comprehensive search was conducted in PubMed, Science Direct, Web of Science, and Google Scholar to identify relevant studies published up to the present articles focusing on nanotechnology-based drug delivery systems using natural products for HCC therapy, including different nanoparticle (NP) formulations and therapeutic interventions, were included. Natural products with anticancer properties have been encapsulated using various nanocarriers such as liposomes, polymeric nanoparticles, and quantum dots, which have improved drug stability, prolonged circulation time, and enhanced targeted delivery to HCC cells. These advancements have led to increased therapeutic efficacy and reduced side effects. Additionally, combining multiple natural products or integrating them with conventional therapies via nanocarriers enables personalized treatment approaches based on patient characteristics and molecular profiles. The integration of nanotechnology with natural products shows great potential for improving HCC treatment outcomes, representing a significant advancement in precision medicine for liver cancer and paving the way for more effective and personalized therapeutic strategies.
肝细胞癌（HCC）是一种侵袭性强且常见的肝癌，预后较差。纳米技术与天然产物相结合已成为提高肝癌治疗效果的一种有前景的策略。本综述评估了目前关于纳米技术在递送天然产物用于肝癌治疗方面的应用的文献。在PubMed、Science Direct、Web of Science和谷歌学术上进行了全面检索，以确定截至目前发表的相关研究。纳入了聚焦于使用天然产物的基于纳米技术的药物递送系统用于肝癌治疗的文章，包括不同的纳米颗粒（NP）制剂和治疗干预措施。具有抗癌特性的天然产物已被封装在各种纳米载体中，如脂质体、聚合物纳米颗粒和量子点，这些纳米载体提高了药物稳定性、延长了循环时间并增强了对肝癌细胞的靶向递送。这些进展提高了治疗效果并减少了副作用。此外，通过纳米载体将多种天然产物组合或与传统疗法整合能够基于患者特征和分子谱实现个性化治疗方法。纳米技术与天然产物的整合在改善肝癌治疗结果方面显示出巨大潜力，代表了肝癌精准医学的一项重大进展，并为更有效和个性化的治疗策略铺平了道路。
