Nimptsch Katharina, Hailer Susanne, Rohrmann Sabine, Gedrich Kurt, Wolfram Gunther, Linseisen Jakob
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Ann Nutr Metab. 2007;51(6):563-70. doi: 10.1159/000114211. Epub 2008 Jan 28.
BACKGROUND/AIMS: To assess dietary and nondietary determinants of serum undercarboxylated osteocalcin (ucOC) as a measure of vitamin K status.
UcOC and total intact osteocalcin (iOC) concentrations were determined by specific ELISA tests in serum samples of 231 male and 320 female participants (18-81 years) of the representative, cross-sectional Bavarian Food Consumption Survey II. Determinants of ucOC were investigated by analysis of variance, Spearman's rank correlation coefficients and logistic regression models.
Mean ucOC serum concentration was 2.46 ng/ml in men and 2.34 ng/ml in women. Corresponding means of the ratio of ucOC to iOC (ucOC/iOC) were 0.28 and 0.29. Concentrations of ucOC and iOC, as well as the ratio of ucOC/iOC, strongly depended on the participant's age. UcOC was influenced by smoking status, sports activity, and the season when blood was collected. Dietary intake of the dominant vitamin K sources, green leafy vegetables and dairy products, as well as the plasma concentration of the carotenoid lutein were inversely associated with serum ucOC values.
In studies using serum ucOC as a measure of vitamin K supply, determinants, especially age, need to be taken into account.
背景/目的：评估血清未羧化骨钙素（ucOC）作为维生素K状态指标的饮食和非饮食决定因素。
在具有代表性的横断面巴伐利亚食物消费调查II的231名男性和320名女性参与者（18 - 81岁）的血清样本中，通过特定的ELISA检测来测定ucOC和总完整骨钙素（iOC）的浓度。通过方差分析、Spearman等级相关系数和逻辑回归模型来研究ucOC的决定因素。
男性的平均血清ucOC浓度为2.46 ng/ml，女性为2.34 ng/ml。ucOC与iOC的相应均值比（ucOC/iOC）分别为0.28和0.29。ucOC和iOC的浓度以及ucOC/iOC比值在很大程度上取决于参与者的年龄。ucOC受吸烟状况、体育活动以及采血季节的影响。主要维生素K来源绿叶蔬菜和乳制品的饮食摄入量以及类胡萝卜素叶黄素的血浆浓度与血清ucOC值呈负相关。
在使用血清ucOC作为维生素K供应指标的研究中，需要考虑决定因素，尤其是年龄。
