Kile Shawn J
University of California, CA, USA.
Psychopharmacol Bull. 2007;40(4):156-67.
Neuroimaging has revitalized the quest for the neurobiology of schizophrenia. The various neuroimaging modalities used in research are described including CT, MRI, PET, SPECT, fMRI, and DTI. Prominent and consistent neuroanatomical findings in the neuroimaging literature of schizophrenia are outlined. These findings, including enlargement of the lateral ventricles, undersized superior temporal gyrus, and prefrontal abnormalities, are supported with neuropathological studies of schizophrenia. Additionally, these findings are correlated with the clinical symptoms of schizophrenia. Neurochemical imaging studies of schizophrenia are reviewed and noted to support dopaminergic dysregulation consistent with the dopamine hypothesis. Finally, current and near-future clinical uses of neuroimaging are described.
神经影像学为探索精神分裂症的神经生物学带来了新活力。文中描述了研究中使用的各种神经影像学方法，包括CT、MRI、PET、SPECT、fMRI和DTI。概述了精神分裂症神经影像学文献中显著且一致的神经解剖学发现。这些发现，包括侧脑室扩大、颞上回过小以及前额叶异常，都得到了精神分裂症神经病理学研究的支持。此外，这些发现与精神分裂症的临床症状相关。文中回顾了精神分裂症的神经化学成像研究，并指出这些研究支持了与多巴胺假说一致的多巴胺调节异常。最后，描述了神经影像学当前及近期的临床应用。
