Reinisch V M, Schankin C J, Felbinger J, Sostak P, Straube A
Oberbayerisches Kopfschmerzzentrum, Neurologische Klinik und Poliklinik, Klinikum Grosshadern der Ludwig-Maximilians-Universität München, Marchioninistrasse 15, 81377, München, Germany.
Schmerz. 2008 Feb;22 Suppl 1:22-30. doi: 10.1007/s00482-007-0609-5.
Chronic headache is still a frequent problem in old age, affecting about 10% of all women and 5% of all men older than 70 years. The incidence of primary headache decreases with advancing age, while that of secondary headache increases. The clinical characteristics of migraine can also change with age; for example, vegetative symptoms are less prominent, and less intense migrainous pain localized predominantly in the neck is frequently reported. Migraine aura can also be experienced more frequently in isolation, without a headache. Hypnic headache is a rare primary headache syndrome that occurs almost exclusively in the elderly. Most of the secondary headache syndromes that occur more frequently in old age present clinically as tension-type headache. Examples of rather common reasons for secondary headache syndromes in the elderly are intracranial space-occupying lesions, ophthalmological problems and autoimmune diseases such as giant cell arteritis. Elderly patients are especially likely to have a number of illnesses at any one time for which they take various medications each day, so that headaches can also quite often be caused by their medication or by withdrawal of these. As a result of such multimorbidity the homeostasis is disturbed in such patients, leading to various conditions that can entail concomitant headaches (sleep apnoea syndrome, dialysis headache, headache attributed to arterial hypertension or hypothyroidism). Familiar facial neuralgias, such as trigeminal neuralgia or postherpetic neuralgia following manifest herpes zoster affecting the face, become markedly more frequent with age. In general, in the treatment of headaches in the elderly it is essential to pay careful attention to potential interactions with the multiple drugs needed because of other diseases; in addition, the comorbidities themselves have to be taken into account, especially depression, anxiety and cognitive impairment, necessitating multimodal, interdisciplinary therapy plans.
慢性头痛在老年人群中仍然是一个常见问题,影响着约10%的70岁以上女性和5%的70岁以上男性。原发性头痛的发病率随年龄增长而降低,而继发性头痛的发病率则升高。偏头痛的临床特征也会随年龄变化;例如,自主神经症状不那么突出,且经常有患者报告颈部为主的偏头痛疼痛程度较轻。偏头痛先兆也可能更频繁地单独出现,而不伴有头痛。睡眠性头痛是一种罕见的原发性头痛综合征,几乎只发生在老年人中。在老年人中更频繁出现的大多数继发性头痛综合征在临床上表现为紧张型头痛。老年人继发性头痛综合征相当常见的原因包括颅内占位性病变、眼科问题以及巨细胞动脉炎等自身免疫性疾病。老年患者尤其可能同时患有多种疾病,每天服用各种药物,因此头痛也常常可能由药物本身或停药引起。由于这种多种疾病共存的情况,这些患者的体内平衡受到干扰,导致各种可能伴有头痛的病症(睡眠呼吸暂停综合征、透析性头痛、归因于动脉高血压或甲状腺功能减退的头痛)。常见的面部神经痛,如三叉神经痛或面部带状疱疹明显发作后的带状疱疹后神经痛,会随着年龄增长而显著增多。一般来说,在治疗老年人头痛时,必须特别注意与因其他疾病所需的多种药物之间的潜在相互作用;此外,还必须考虑到合并症本身,尤其是抑郁症、焦虑症和认知障碍,这就需要制定多模式、跨学科的治疗方案。