Vesely Jan, Rios Ramon, Ibrahem Ismail, Zhao Gui-Ling, Eriksson Lars, Córdova Armando
Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, 106 91 Stockholm (Sweden).
Chemistry. 2008;14(9):2693-8. doi: 10.1002/chem.200701918.
A regiospecific, highly chemo-, diastereo-, and enantioselective one-pot catalytic cascade synthesis of cycloheptane derivatives is presented. In this chiral-amine-catalyzed asymmetric process, six new bonds and five new stereocenters were formed with excellent stereocontrol (>25:1 d.r. and 98- >99 ee).
本文报道了一种区域特异性、高度化学、非对映和对映选择性的一锅法催化串联合成环庚烷衍生物的方法。在这种手性胺催化的不对称过程中，形成了六个新键和五个新的立体中心，具有出色的立体控制（>25:1的非对映体比例和98->99%的对映体过量）。
