二烯钛配合物作为构建三元或五元碳环的合成中间体。
Diene-titanium complexes as synthetic intermediates for the construction of three- or five-membered carbocycles.
作者信息
Bertus Philippe, Menant Christine, Tanguy Chloé, Szymoniak Jan
机构信息
ICMR - UMR 6229, CNRS - Université de Reims Champagne-Ardenne, BP 1039, 51687 Reims Cedex 2, France.
出版信息
Org Lett. 2008 Mar 6;10(5):777-80. doi: 10.1021/ol702917c. Epub 2008 Jan 30.
PMID:18229933
Abstract
It has been shown that diene-titanium complexes exhibit substrate-dependent 1,2- or 1,4-dicarbanion reactivity. On this basis, 3-cyclopentenylamines and spiro-vinylcyclopropane lactams were easily prepared by using homoallylic Grignard reagents, Ti(O-i-Pr)4, and nitriles or cyanoesters, respectively.
摘要
已表明二烯钛配合物表现出底物依赖性的1,2-或1,4-二碳负离子反应性。在此基础上，分别使用高烯丙基格氏试剂、Ti(O-i-Pr)4和腈或氰基酯，可轻松制备3-环戊烯基胺和螺环乙烯基环丙烷内酰胺。
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