通过氨基甲酸酯有机锌卡宾快速合成氨环丙烷。
A rapid route to aminocyclopropanes via carbamatoorganozinc carbenoids.
机构信息
Department of Chemistry, University College London, 20 Gordon St, London, WC1H 0AJ (UK) http://www.ucl.ac.uk/chemistry; Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, Ube 755-8611 (Japan).
出版信息
Angew Chem Int Ed Engl. 2013 Sep 16;52(38):10060-3. doi: 10.1002/anie.201304720. Epub 2013 Aug 1.
Abstract
Easy as 1,2,3: Reaction of methyl carbamate, triethyl orthoformate, and readily available alkenes provides a highly practical preparation of protected aminocyclopropanes. The reaction proceeds with preferential cis addition to alkenes, and cleavage of the methyl carbamate gives the free aminocyclopropanes as their HI salts.
摘要
易如反掌
氨基甲酸甲酯、原甲酸三乙酯和易得的烯烃反应可高度实用地制备保护的氨基环丙烷。该反应优先顺式加成于烯烃，并且通过裂解氨基甲酸甲酯以其 HI 盐的形式得到游离的氨基环丙烷。
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