Nelson T J, Alkon D L
Neural Systems Section, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, MD 20892.
Mol Neurobiol. 1991;5(2-4):315-28. doi: 10.1007/BF02935554.
Inhibition of potassium channels is possibly the first step in the sequence of biochemical events leading to memory formation. These channels appear to be regulated directly or indirectly by GTP-binding proteins (G proteins), which may themselves be affected by phosphorylation and dephosphorylation in response to elevated calcium levels or other phenomena resulting from the blockage of the potassium channels. A wide variety of cellular phenomena, from transcriptional changes to axonal transport, are thus capable of being initiated by these events.
钾通道的抑制可能是导致记忆形成的一系列生化事件中的第一步。这些通道似乎直接或间接受鸟苷三磷酸结合蛋白（G蛋白）调节，而G蛋白本身可能会因钙水平升高或钾通道阻断引发的其他现象而受到磷酸化和去磷酸化的影响。因此，从转录变化到轴突运输等各种各样的细胞现象都能够由这些事件引发。
