[荷兰甲型肝炎的分子流行病学；分离病毒株分型的实用性]
[The molecular epidemiology of hepatitis A in The Netherlands; the usefulness of typing isolated viral strains].
作者信息
Bruisten S M, Tjon G M S, van den Hoek J A R, Wijkmans C J, Götz H M, Coutinho R A
机构信息
GGD Amsterdam, Cluster Infectieziekten, Streeklaboratorium, Nieuwe Achtergracht 100, 1018 WT Amsterdam.
出版信息
Ned Tijdschr Geneeskd. 2007 Dec 15;151(50):2779-86.
OBJECTIVE
To investigate the epidemiological links between several outbreaks of hepatitis A in The Netherlands (2001-2004).
DESIGN
Descriptive.
METHOD
Blood samples taken in connection with reports of hepatitis A to municipal health centres from 2001-2004, were typed by determining the nucleotide sequence of the VP3-VP1 and the VP1-P2A regions of the genome of the hepatitis A virus (HAV). Genetic distances were represented graphically by means of a phylogenetic tree.
RESULTS
The study into the spread of various subtypes of HAV showed a clear link between the HAV-(sub)genotype and risk of transmission: in men that have sex with men only genotype 1A occurred, in travellers to African countries genotype 1B was predominantly seen.
CONCLUSION
A database containing various viral strains from people with hepatitis A in The Netherlands could, if kept up to date, be used as an aid in confirming the classical way of tracing sources as well as for the evaluation of preventative measures.
目的
调查荷兰几次甲型肝炎暴发（2001 - 2004年）之间的流行病学关联。
设计
描述性研究。
方法
2001年至2004年期间，与向市政卫生中心报告的甲型肝炎病例相关采集的血样，通过测定甲型肝炎病毒（HAV）基因组VP3 - VP1和VP1 - P2A区域的核苷酸序列进行分型。遗传距离通过系统发育树以图形方式表示。
结果
对HAV各种亚型传播的研究表明，HAV（亚）基因型与传播风险之间存在明显关联：在男男性行为者中仅出现1A基因型，在前往非洲国家的旅行者中主要观察到1B基因型。
结论
一个包含来自荷兰甲型肝炎患者的各种病毒株的数据库，如果保持更新，可用于辅助确认追踪传染源的传统方法以及评估预防措施。
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