Macedo C F, Tomaz C
Laboratório de Psicobiologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brasil.
Braz J Med Biol Res. 1991;24(2):181-5.
Experiments were carried out in order to determine whether groups of rats (N = 7) with unilateral or bilateral ablation of the neocortex or with removal of the neocortex plus the hippocampus of either hemisphere could learn to escape from a tank of water (57 cm in diameter) climbing a visible platform when trained for 6 consecutive days. Comparison of the swimming escape latencies among groups showed no statistically significant differences, although over the first four trial blocks the decorticate group was slower (77.19 +/- 39.31, 52.45 +/- 32.37, 31.18 +/- 13.62 and 15.74 +/- 10.94 s, respectively) than the other groups, whose latencies ranged from about 70 s (the longest in the first trial block) to 8 s (the longest in the fourth trial block). Nevertheless, hemi- and bilaterally decorticate rats were still able to learn the water maze task. The same was observed for hemidecorticate plus hemihippocampectomized rats. These results indicate that the neocortex, and the hippocampus in the absence of the neocortex, is not essential for spatial localization using a cue-learning strategy.
进行了实验，以确定单侧或双侧切除新皮层的大鼠组（N = 7），或切除任一脑半球的新皮层加海马体的大鼠组，在连续训练6天时，是否能够学会从一个直径57厘米的水箱中爬上可见平台逃生。尽管在最初的四个试验组中，去皮质组比其他组慢（分别为77.19 +/- 39.31、52.45 +/- 32.37、31.18 +/- 13.62和15.74 +/- 10.94秒），其他组的潜伏期从大约70秒（第一个试验组中最长）到8秒（第四个试验组中最长），但各实验组间游泳逃生潜伏期的比较没有显示出统计学上的显著差异。然而，单侧和双侧去皮质的大鼠仍然能够学会水迷宫任务。单侧去皮质加单侧海马切除的大鼠也观察到同样的情况。这些结果表明，新皮层以及在没有新皮层时的海马体，对于使用线索学习策略进行空间定位不是必需的。
