来自百里香腊菊的线性二萜类化合物及其衍生物对昆虫生长的调节作用。

Insect growth regulatory effects of linear diterpenoids and derivatives from Baccharis thymifolia.

作者信息

Juan Hikawczuk Virginia E, Saad J Roberto, Giordano Oscar S, García Celina, Martín Tomás, Martín Víctor S, Sosa Marta E, Tonn Carlos E

机构信息

Facultad de Química, Bioquíca y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, 5700 San Luis, Argentina.

出版信息

J Nat Prod. 2008 Feb;71(2):190-4. doi: 10.1021/np070392o. Epub 2008 Jan 31.

DOI:10.1021/np070392o

PMID:18232640

Abstract

Linear diterpenes isolated from aerial parts of Baccharis thymifolia ( 1- 3) were tested for insect growth inhibitory activity against Tenebrio molitor larvae. Compounds 4- 16 were prepared by various chemical transformations. The diterpenes 6,10-( E,E)-thymifodioic acid ( 1), the butenolide 3, and the derivatives 4, 11, and 14 produced developmental deficiencies in assays using topical application on fifth instar larvae of T. molitor. Compound 3 is a new natural product.

摘要

从百里香巴卡里斯地上部分分离得到的线性二萜（1-3），针对黄粉虫幼虫进行了昆虫生长抑制活性测试。化合物4-16通过各种化学转化制备而成。二萜6,10-(E,E)-百里香二酸（1）、丁烯内酯3以及衍生物4、11和14，在对黄粉虫五龄幼虫进行局部涂抹的试验中导致发育缺陷。化合物3是一种新的天然产物。