克拉苏胺A - C和克拉苏瓦汀D的全合成。

Total syntheses of clausamines A-C and clausevatine D.

作者信息

Lebold Terry P, Kerr Michael A

机构信息

Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7.

出版信息

Org Lett. 2008 Mar 6;10(5):997-1000. doi: 10.1021/ol703085f. Epub 2008 Jan 31.

DOI:10.1021/ol703085f

PMID:18232706

Abstract

The first total syntheses of clausamines A-C and clausevatine D are reported. The key step involves a Diels-Alder reaction between an imine quinone and cyclic diene, allowing for the subsequent construction of the carbazole core in a regiospecific manner. Stereochemistry of the natural products is also discussed.

摘要

据报道，首次完成了克拉苏胺A - C和克拉苏瓦汀D的全合成。关键步骤涉及亚胺醌与环状二烯之间的狄尔斯-阿尔德反应，从而能够以区域特异性方式随后构建咔唑核心。还讨论了天然产物的立体化学。