克劳赖拉 A-D，从胡桐根源生的细胞毒素咔唑生物碱。

Claurailas A-D, cytotoxic carbazole alkaloids from the roots of Clausena harmandiana.

机构信息

Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

出版信息

J Nat Prod. 2011 Feb 25;74(2):208-12. doi: 10.1021/np100654m. Epub 2011 Feb 8.

DOI:10.1021/np100654m

PMID:21302964

Abstract

Four new carbazole alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with IC(50) values ranging from 1.3 to 2.7 μM. Compound 7 showed no cytotoxicity against Vero cells.

摘要

从胡桐属植物中分离得到了四个新的咔唑生物碱，克劳雷阿斯 A-D（1-4），以及 12 个已知的咔唑和三个已知的香豆素。庚基菲宁（6）和 7-甲氧基庚基菲宁（7）对 NCI-H187 和 KB 细胞系表现出强烈的细胞毒性，IC50 值范围为 1.3 至 2.7 μM。化合物 7 对 Vero 细胞没有细胞毒性。