Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
J Nat Prod. 2011 Feb 25;74(2):208-12. doi: 10.1021/np100654m. Epub 2011 Feb 8.
Four new carbazole alkaloids, claurailas A-D (1-4), as well as 12 known carbazoles and three known coumarins were isolated from the roots of Clausena harmandiana. Heptaphylline (6) and 7-methoxyheptaphylline (7) showed strong cytotoxicity against NCI-H187 and KB cell lines with IC(50) values ranging from 1.3 to 2.7 μM. Compound 7 showed no cytotoxicity against Vero cells.
从胡桐属植物中分离得到了四个新的咔唑生物碱，克劳雷阿斯 A-D（1-4），以及 12 个已知的咔唑和三个已知的香豆素。庚基菲宁（6）和 7-甲氧基庚基菲宁（7）对 NCI-H187 和 KB 细胞系表现出强烈的细胞毒性，IC50 值范围为 1.3 至 2.7 μM。化合物 7 对 Vero 细胞没有细胞毒性。
