[乙二胺四乙酸二钠（Na2EDTA）和四环素对耐药菌的作用。体外研究]
[Effects of disodium salt of ethylenediaminetetraacetic acid (Na2EDTA) and tetracyclines on drug resistant bacteria. Studies in vitro].
作者信息
Rudy M, Radosz-Komoniewska H, Nowakowska M, Ekiel A
机构信息
II Katedra i Zakład Mikrobiologii Slaskiej Akademii Medycznej, Katowicach.
出版信息
Med Dosw Mikrobiol. 1991;43(3-4):127-34.
An effect of Na2EDTA and tetracycline (oxytetracycline and doxycycline) resistant strains of Staphylococcus aureus and Pseudomonas aeruginosa was tested. The strains were isolated from clinical specimens. The tests were performed in vitro by serial dilutions of the drugs in liquid medium. MIC for Na2EDTA, tetracyclines and a combination of Na2EDTA and tetracyclines was determined. It was shown that the combination of oxytetracycline or doxycycline with Na2EDTA caused changes in sensitivity of Staphylococcus aureus and Pseudomonas aeruginosa resistant to these antibiotics. After an application of the mixture of various concentrations of tetracycline and Na2EDTA it was observed that, with the reduction of the effective Na2EDTA dose by about half, the lowest concentrations of tetracyclines inhibiting the growth of resistant bacteria were 2-64 times lower than MIC values of antibiotics without Na2EDTA.
测试了乙二胺四乙酸二钠（Na2EDTA）与金黄色葡萄球菌和铜绿假单胞菌的四环素（土霉素和强力霉素）耐药菌株之间的作用。这些菌株是从临床标本中分离出来的。通过在液体培养基中对药物进行系列稀释，在体外进行测试。测定了Na2EDTA、四环素以及Na2EDTA与四环素组合的最低抑菌浓度（MIC）。结果表明，土霉素或强力霉素与Na2EDTA的组合导致了对这些抗生素耐药的金黄色葡萄球菌和铜绿假单胞菌的敏感性发生变化。在应用不同浓度的四环素和Na2EDTA混合物后，观察到，随着有效Na2EDTA剂量降低约一半，抑制耐药菌生长的四环素最低浓度比不含Na2EDTA的抗生素的MIC值低2至64倍。
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