Rudy M, Rogala-Zawada D, Kapp-Burzyńska Z, Kłaptocz B, Wilk I
II Katedry i Zakładu Mikrobiologii Sl. AM, Katowicach.
Pol Tyg Lek. 1992;47(36-37):799-801.
Effect of Na2EDTA and doxycycline applied alone and in combination in the treatment of experimentally induced dermatitis in rabbits with Staphylococcus aureus resistant to tetracyclines was studied. The rabbits were divided into three groups. The animals of group I were treated locally with the ointment containing 1% doxycycline or 1% Na2EDTA. In group II topical treatment was applied by means of injections of Na2EDTA solution in doses of 12.5 and 6.25 mg Na2EDTA per 1 kg/body weight. Group III was also treated locally with Na2EDTA solution like in group II, but additionally doxycycline in a dose of 50 micrograms per 1 kg/body weight was given i.v. Favourable therapeutic results were observed in the case of local, simultaneous application of Na2EDTA and doxycycline, or local application of Na2EDTA, and intravenous administration of doxycycline. However, the best therapeutic effect was seen in the case of local, simultaneous application of the ointment containing Na2EDTA and doxycycline.
研究了单独及联合应用乙二胺四乙酸二钠（Na2EDTA）和强力霉素对四环素耐药金黄色葡萄球菌诱导的兔实验性皮肤炎的治疗效果。将兔子分为三组。第一组动物局部使用含1%强力霉素或1% Na2EDTA的软膏进行治疗。第二组通过注射每1千克体重12.5毫克和6.25毫克Na2EDTA的溶液进行局部治疗。第三组也像第二组一样用Na2EDTA溶液进行局部治疗，但另外静脉注射每1千克体重50微克的强力霉素。在局部同时应用Na2EDTA和强力霉素，或局部应用Na2EDTA并静脉注射强力霉素的情况下，观察到了良好的治疗效果。然而，在局部同时应用含Na2EDTA和强力霉素的软膏时，治疗效果最佳。
