I型和III型成骨不全症患者的全身骨矿物质及抗酒石酸酸性磷酸酶水平

Total body bone mineral and tartrate-resistant acid phosphatase levels in type I and III osteogenesis imperfecta.

作者信息

Rico H, Revilla M, Iritia M, Arribas I, Fernando Villa L

机构信息

Department of Medicine and Rheumatology Section, Alcalá de Henares University, Madrid, Spain.

出版信息

Miner Electrolyte Metab. 1991;17(6):396-8.

PMID:1823391

Abstract

Serum tartrate-resistant acid phosphatase (TRAP) and total body bone mineral content (TBBM) were determined in a group of 16 children with osteogenesis imperfecta (OI) aged 5-14 years, 9 of whom suffered from type I and 7 from type III OI. TRAP and TBBM were also determined in a group of 26 normal children of a similar age range. TRAP levels were reduced in the type I and III OI groups (p less than 0.001). TBBM levels were lower in type I OI than in type III (p less than 0.005), and both OI groups showed reduced levels compared to the controls (p less than 0.001). The control group subjects showed a significant correlation between TRAP and TBBM (r = -0.62; p less than 0.001) which was not observed in the OI groups. Since TRAP is a biological marker of bone turnover, the results suggest that bone turnover is reduced in OI.

摘要

对一组16名年龄在5至14岁的成骨不全症（OI）儿童进行了血清抗酒石酸酸性磷酸酶（TRAP）和全身骨矿物质含量（TBBM）的测定，其中9名患有I型OI，7名患有III型OI。还对一组年龄范围相似的26名正常儿童进行了TRAP和TBBM的测定。I型和III型OI组的TRAP水平降低（p<0.001）。I型OI的TBBM水平低于III型（p<0.005），并且与对照组相比，两个OI组的水平均降低（p<0.001）。对照组受试者的TRAP和TBBM之间存在显著相关性（r = -0.62；p<0.001），而在OI组中未观察到这种相关性。由于TRAP是骨转换的生物学标志物，结果表明OI患者的骨转换降低。