Rajtár M, László A, Beviz J, Bossányi A, Almási L, Csernay L
Központi Izotópdiagnosztikai Laboratórium, Radiológiai Klinika, Szent-Györgyi Albert Orvostudományi Egyetem, Szeged.
Orv Hetil. 1996 Jul 14;137(28):1519-23.
Bone mineral content (BMC) in the radius of 23 osteogenesis imperfecta (OI) patients (1-26 yr) was measured with SPA technique. Comparing the values of OI type I. patients with that of type III. patients, the decrease of BMC was more prominent in the latter group, however, the two group hadn't been distinct from each other at p < 0.05 level. Based on the measurements of 39 relatives (mother, father, brother) the method seems not to be helpful in screening of gene-carrying relatives because of the high variability of the phenotype of the disease. Follow-up SPA studies-avoiding the repositioning errors-inform about the therapeutic effect.
采用单光子吸收法（SPA）技术测量了23例成骨不全症（OI）患者（年龄1 - 26岁）桡骨的骨矿物质含量（BMC）。比较I型OI患者和III型OI患者的BMC值，后者BMC的降低更为显著，然而，两组在p < 0.05水平上并无显著差异。基于对39名亲属（母亲、父亲、兄弟）的测量，由于该疾病表型的高度变异性，该方法似乎无助于筛查携带基因的亲属。后续避免重新定位误差的SPA研究可提供有关治疗效果的信息。
