Oh So Yeon, Kim Jee Hyun, Lee Keun-Wook, Bang Soo-Mee, Hwang Jin-Hyeok, Oh Doyeun, Lee Jong Seok
Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 300, Goomi-dong, Bundang-gu, Seongnam, 463-707, Republic of Korea.
Thromb Res. 2008;122(4):485-90. doi: 10.1016/j.thromres.2007.12.015. Epub 2008 Jan 30.
Pancreatic adenocarcinoma is one of the cancers most frequently associated with venous thromboembolism (VTE), with the varying incidences of 10%-20% reported in Western countries. Asians are known to have a lower risk for VTE than Caucasians, but few studies have been conducted regarding the incidence of VTE in Asian cancer patients.
Incidence of radiologically confirmed VTE was assessed by review of medical records of all patients histologically diagnosed with advanced pancreatic adenocarcinoma, with follow-up conducted at a regional teaching hospital from Jun 2003 to Dec 2005.
Seventy five patients with advanced pancreatic adenocarcinoma were identified for evaluation (M:F=44:31, locally advanced:metastatic=25:50, median age:67 years). Four patients (5.3%) developed VTE during median follow-up period of 124 days. Three of four patients had metastatic disease and were receiving chemotherapy when VTE developed. The mean time from cancer diagnosis to the detection of VTE was 160 days. No episodes of peripheral arterial thrombosis were detected, but three multiple cerebral infarctions occurred, which proved fatal in all three. Median survival time was shorter in patients with VTE than those without, but the difference was not statistically significant (4.3 vs 6.6 months).
The incidence of VTE complications in Korean patients with advanced pancreatic cancer was 5.3%, which is lower than that observed in other ethnic groups. Our study warrants further prospective investigations on the incidence and mechanism of VTE and cerebral infarctions in cancer patients of different ethnic groups.
胰腺腺癌是最常与静脉血栓栓塞（VTE）相关的癌症之一，西方国家报道的发病率在10%至20%之间。已知亚洲人发生VTE的风险低于白种人，但关于亚洲癌症患者VTE发病率的研究较少。
通过回顾2003年6月至2005年12月在一家地区教学医院接受组织学诊断为晚期胰腺腺癌的所有患者的病历，评估经放射学确诊的VTE发病率。
共确定75例晚期胰腺腺癌患者进行评估（男:女 = 44:31，局部晚期:转移性 = 25:50，中位年龄:67岁）。在中位随访期124天内，4例患者（5.3%）发生VTE。4例患者中有3例患有转移性疾病，在发生VTE时正在接受化疗。从癌症诊断到检测到VTE的平均时间为160天。未检测到外周动脉血栓形成事件，但发生了3例多发性脑梗死，3例均死亡。发生VTE的患者中位生存时间比未发生VTE的患者短，但差异无统计学意义（4.3个月对6.6个月）。
韩国晚期胰腺癌患者VTE并发症的发生率为5.3%，低于其他种族群体。我们的研究值得对不同种族癌症患者VTE和脑梗死的发病率及机制进行进一步的前瞻性研究。
