Zhou Yuan, Shu Ni, Liu Yong, Song Ming, Hao Yihui, Liu Haihong, Yu Chunshui, Liu Zhening, Jiang Tianzi
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, PR China.
Schizophr Res. 2008 Mar;100(1-3):120-32. doi: 10.1016/j.schres.2007.11.039. Epub 2008 Jan 30.
Hippocampus has been implicated in participating in the pathophysiology of schizophrenia. However, the functional and anatomical connectivities between hippocampus and other regions are rarely concurrently investigated in schizophrenia. In the present study, both functional magnetic resonance imaging (fMRI) during rest and diffusion tensor imaging (DTI) were performed on 17 patients with paranoid schizophrenia and 14 healthy subjects. Resting-state functional connectivities of the bilateral hippocampi were separately analyzed by selecting the anterior hippocampus as region of interest. The fornix body was reconstructed by diffusion tensor tractography, and the integrity of this tract was evaluated using fractional anisotropy (FA). In patients with schizophrenia, the bilateral hippocampi showed reduced functional connectivities to some regions which have been reported to be involved in episodic memory, such as posterior cingulate cortex, extrastriate cortex, medial prefrontal cortex, and parahippocampus gyrus. We speculated that these reduced connectivity may reflect the disconnectivity within a neural network related to the anterior hippocampus in schizophrenia. Meanwhile the mean FA of the fornix body was significantly reduced in patients, indicating the damage in the hippocampal anatomical connectivity in schizophrenia. The concurrence of the functional disconnectivity and damaged anatomical connectivity between the hippocampus and other regions in schizophrenia suggest that the functional-anatomical relationship need to be further investigated.
海马体已被认为参与了精神分裂症的病理生理过程。然而，在精神分裂症中，海马体与其他区域之间的功能和解剖连接很少同时进行研究。在本研究中，对17例偏执型精神分裂症患者和14名健康受试者进行了静息态功能磁共振成像（fMRI）和扩散张量成像（DTI）。通过选择前海马体作为感兴趣区域，分别分析双侧海马体的静息态功能连接。通过扩散张量纤维束成像重建穹窿体，并使用分数各向异性（FA）评估该纤维束的完整性。在精神分裂症患者中，双侧海马体与一些据报道参与情景记忆的区域，如后扣带回皮质、纹外皮质、内侧前额叶皮质和海马旁回，之间的功能连接减少。我们推测这些连接减少可能反映了精神分裂症中与前海马体相关的神经网络内的连接中断。同时，患者穹窿体的平均FA显著降低，表明精神分裂症中海马体解剖连接受损。精神分裂症中海马体与其他区域之间功能连接中断和解剖连接受损的同时出现表明，功能 - 解剖关系需要进一步研究。
