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挥鞭样损伤相关疾病个体亚组的生活质量

Quality of life in subgroups of individuals with whiplash-associated disorders.

作者信息

Wallin Mia K M, Raak Ragnhild I

机构信息

Department of Social and Welfare Studies, University of Linköping, Dragsgatan 7, SE-601 74 Norrköping, Sweden.

出版信息

Eur J Pain. 2008 Oct;12(7):842-9. doi: 10.1016/j.ejpain.2007.12.008. Epub 2008 Jan 29.

Abstract

BACKGROUND

The term whiplash associated disorders (WAD) includes a wide range of complaints, with neck pain as predominating symptom. Living with long term pain influences quality of life. In previous studies of other chronic pain patients, subgrouping has been made according to thermal pain thresholds measured in quantitative sensory testing (QST).

AIMS

The aims of the present study are threefold, (1) to evaluate thermal pain thresholds and health related quality of life in WAD patients compared to healthy pain-free individuals, (2) to explore whether subgrouping of the WAD patients is possible according to thermal pain thresholds over trapezius, and if so (3) to explore differences between the subgroups.

METHODS

Twenty-six patients with WAD and 18 healthy pain-free controls took part in the study. Thermal pain thresholds were measured in two sites (over the thenar and the trapezius muscle) using quantitative sensory testing (QST). Health related quality of life (HRQoL) was assessed using the SF-36. The visual analogue scale was used to rate pain intensity and unpleasantness related to the experimental situation.

RESULTS

WAD patients are more sensitive to thermal pain, and scored lower on the SF-36 in all scales when compared with healthy pain-free individuals. After analyzing clusters (K-means algorithm) two subgroups of WAD emerge, pain insensitive and pain sensitive. The pain insensitive group differed significantly from the pain sensitive group in the Role Emotional subscale of SF-36 (p=0.025).

CONCLUSIONS

Thermal pain hyperalgesia, especially for cold, seems to be a determinant for subgrouping WAD patients. These results support that such a classification of a heterogenous group could be of importance in tailoring treatment and early interventions.

摘要

背景

挥鞭样损伤相关疾病(WAD)这一术语涵盖了广泛的症状,其中颈部疼痛是主要症状。长期忍受疼痛会影响生活质量。在之前对其他慢性疼痛患者的研究中,已根据定量感觉测试(QST)测量的热痛阈值进行了亚组划分。

目的

本研究有三个目的,(1)与无疼痛的健康个体相比,评估WAD患者的热痛阈值和与健康相关的生活质量;(2)探讨是否可以根据斜方肌上的热痛阈值对WAD患者进行亚组划分,如果可以,(3)探讨各亚组之间的差异。

方法

26名WAD患者和18名无疼痛的健康对照者参与了本研究。使用定量感觉测试(QST)在两个部位(大鱼际和斜方肌)测量热痛阈值。使用SF-36评估与健康相关的生活质量(HRQoL)。视觉模拟量表用于对与实验情况相关的疼痛强度和不适感进行评分。

结果

与无疼痛的健康个体相比,WAD患者对热痛更敏感,并且在SF-36的所有量表上得分更低。在分析聚类(K均值算法)后,出现了WAD的两个亚组,即疼痛不敏感组和疼痛敏感组。在SF-36的角色情绪子量表中,疼痛不敏感组与疼痛敏感组有显著差异(p = 0.025)。

结论

热痛觉过敏,尤其是对冷的热痛觉过敏,似乎是WAD患者亚组划分的一个决定因素。这些结果支持,对这样一个异质性群体进行这种分类可能对定制治疗和早期干预具有重要意义。

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