刺激频率对泮库溴铵和罗库溴铵所致阻滞的影响：大鼠膈神经-膈肌标本的研究
Influence of stimulus frequency on blockade induced by pancuronium and rocuronium: study on rats phrenic nerve-diaphragm preparation.
作者信息
Braga Angélica de Fátima de Assunção, Munoz Derli Conceição, Braga Franklin Sarmento da Silva, Araujo Daniele Ribeiro de, Potério Glória Maria Braga, Mantovani Mario
机构信息
Department of Anesthesiology, Faculty of Medical Sciences, UNICAMP, São Paulo, Brazil.
出版信息
Acta Cir Bras. 2007 Nov-Dec;22(6):446-50. doi: 10.1590/s0102-86502007000600006.
PURPOSE
To evaluate the influence of two stimulation frequencies on the installation of neuromuscular blockade produced by pancuronium and rocuronium on the rat diaphragm.
METHODS
Diaphragms were submitted to an indirect frequency stimulation of 0.1 and 1 Hz (Groups I and II, respectively). Subgroups were formed (n=5) according to the neuromuscular blocker employed (pancuronium-2 microg/ml and rocuronium-4 microg/ml). The twitch height depression was evaluated at 5, 15 and 30 minutes after adding the neuromuscular blocker.
RESULTS
The decrease in twitch height was greater (p<0.01) with a frequency of 1 Hz at all time periods studied both in preparations that are blocked with pancuronium and in those that are blocked with rocuronium.
CONCLUSION
The frequency of stimulation interferes significantly with the installation of neuromuscular blockade produced by pancuronium and rocuronium, since the reduction in amplitude of the rat diaphragm response was greater for 1 Hz frequencies, at all periods studied.
目的
评估两种刺激频率对泮库溴铵和罗库溴铵在大鼠膈肌上产生神经肌肉阻滞作用的影响。
方法
分别对膈肌施加0.1 Hz和1 Hz的间接频率刺激（分别为I组和II组）。根据所使用的神经肌肉阻滞剂（泮库溴铵-2微克/毫升和罗库溴铵-4微克/毫升）形成亚组（n = 5）。在加入神经肌肉阻滞剂后5、15和30分钟评估抽搐高度降低情况。
结果
在所有研究时间段内，无论是用泮库溴铵阻滞的制剂还是用罗库溴铵阻滞的制剂，1 Hz频率时抽搐高度的降低幅度都更大（p < 0.01）。
结论
刺激频率显著影响泮库溴铵和罗库溴铵产生的神经肌肉阻滞作用，因为在所有研究时间段内，1 Hz频率时大鼠膈肌反应的幅度降低更大。
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