Mózsik G, Szolcsányi J, Dömötör A
First Department of Medicine, Medical and Health Centre, University of Pécs, H-7643, Pécs, Hungary.
Inflammopharmacology. 2007 Dec;15(6):232-45. doi: 10.1007/s10787-007-1584-2.
Capsaicin has been found to act on the capsaicin sensitive afferent nerves in animal experiments.
The specific action of capsaicin on sensory afferent nerves affecting gastrointestinal (GI) functions was investigated in human GI physiology and pathology using pharmacological approaches.
Observations were carried out in 98 normal healthy human subjects and in 178 patients with different gastrointestinal diseases (gastritis, erosions, ulcer, polyps, cancer, inflammatory bowel diseases, colorectal polyps, cancers). The gastric secretory responses and their chemical composition, gastric emptying, sugar loading test, gastric transmucosal potential difference (GTPD) were investigated following with administration of (a) capsaicin alone, (b) ethanol alone or with capsaicin, and (c) indomethacin-induced gastric mucosal microbleeding with or without capsaicin, both before and after 2 weeks capsaicin treatment. Immunohistochemical investigations were performed to establish the presence of the capsaicin (vanillinoid) receptor (TRVP1), CGRP and SP in the whole GI tract. Conventional molecular pharmacological methods were applied to study the effects of capsaicin and other drugs for their inhibitory effects on the gastric basal acid output.
Capsaicin decreased the gastric basal output, enhanced the "non parietal" (buffering) component of gastric secretory responses, gastric emptying, release of glucagon. Capsaicin prevents the indomethacin- and ethanol-induced gastric mucosal injury, while capsaicin itself enhanced the gastric transmucosal potential difference (GTPD). The capsaicin reactive receptors, TRVP1, CGRP, SP were detected in the GI mucosa in patients with different GI disorders, but their presence varied in acute and chronic GI disorders.
Application of capsaicin offers a new research tool for understanding the vanilloid-related events of human GI functions in relation to normal physiology and in disease states and the use of pharmacological agents affecting these receptor mediated changes.
在动物实验中发现辣椒素作用于对辣椒素敏感的传入神经。
采用药理学方法，在人体胃肠生理学和病理学研究中，探究辣椒素对影响胃肠（GI）功能的感觉传入神经的具体作用。
对98名正常健康受试者和178名患有不同胃肠疾病（胃炎、糜烂、溃疡、息肉、癌症、炎症性肠病、大肠息肉、癌症）的患者进行观察。在给予（a）单独辣椒素、（b）单独乙醇或乙醇与辣椒素、（c）吲哚美辛诱导的胃黏膜微出血伴或不伴辣椒素前后，以及辣椒素治疗2周前后，研究胃分泌反应及其化学成分、胃排空、糖负荷试验、胃黏膜跨膜电位差（GTPD）。进行免疫组织化学研究以确定整个胃肠道中辣椒素（香草酸）受体（TRVP1）、降钙素基因相关肽（CGRP）和P物质（SP）的存在情况。应用传统分子药理学方法研究辣椒素和其他药物对胃基础酸分泌的抑制作用。
辣椒素降低胃基础分泌量，增强胃分泌反应的“非壁细胞”（缓冲）成分、胃排空和胰高血糖素释放。辣椒素可预防吲哚美辛和乙醇诱导的胃黏膜损伤，而辣椒素本身可增强胃黏膜跨膜电位差（GTPD）。在患有不同胃肠疾病的患者的胃肠黏膜中检测到辣椒素反应性受体TRVP1、CGRP、SP，但其在急性和慢性胃肠疾病中的存在情况有所不同。
辣椒素的应用为理解与正常生理学和疾病状态相关的人体胃肠功能中与香草酸相关的事件，以及影响这些受体介导变化的药物的使用提供了一种新的研究工具。
