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The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K ATP Signaling Pathway.

作者信息

de Alencar Nylane Maria Nunes, Pinheiro Rachel Sindeaux Paiva, de Figueiredo Ingrid Samantha Tavares, Luz Patrícia Bastos, Freitas Lyara Barbosa Nogueira, de Souza Tamiris de Fátima Goebel, do Carmo Luana David, Marques Larisse Mota, Ramos Marcio Viana

机构信息

Departamento de Fisiologia e Farmacologia, UFC, Coronel Nunes de Melo 1127, Rodolfo Teófilo, 60430-270 Fortaleza, CE, Brazil.

Centro Universitário Estácio do Ceará, Via Corpvs, Rua Eliseu Uchoa Becco, No. 600, Bairro Água Fria, 60810-270 Fortaleza, CE, Brazil.

出版信息

Evid Based Complement Alternat Med. 2015;2015:706782. doi: 10.1155/2015/706782. Epub 2015 Dec 14.

DOI:10.1155/2015/706782
PMID:26788111
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4691623/
Abstract

Plumeria rubra (Apocynaceae) is frequently used in folk medicine for the treatment of gastrointestinal disorders, hepatitis, and tracheitis, among other infirmities. The aim of this study was to investigate the gastroprotective potential of a protein fraction isolated from the latex of Plumeria rubra (PrLP) against ethanol-induced gastric lesions and describe the underlying mechanisms. In a dose-dependent manner, the pretreatment with PrLP prevented ethanol-induced gastric lesions in mice after single intravenous administration. The gastroprotective mechanism of PrLP was associated with the involvement of prostaglandins and balance of oxidant/antioxidant factors. Secondarily, the NO/cGMP/KATP pathway and activation of capsaicin-sensitive primary afferents were also demonstrated as part of the mechanism. This study shows that proteins extracted from the latex of P. rubra prevent gastric lesions induced in experimental animals. Also, the results support the use of the plant in folk medicine.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/b975da3df18c/ECAM2015-706782.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/020c91d5b35d/ECAM2015-706782.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/3ae70b598a50/ECAM2015-706782.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/3d0224981065/ECAM2015-706782.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/b2e73df75a73/ECAM2015-706782.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/a33187840533/ECAM2015-706782.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/7c7dee704ca8/ECAM2015-706782.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/4633af9a7fdb/ECAM2015-706782.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/cb2db1d321c9/ECAM2015-706782.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/b975da3df18c/ECAM2015-706782.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/020c91d5b35d/ECAM2015-706782.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/3ae70b598a50/ECAM2015-706782.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/3d0224981065/ECAM2015-706782.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/b2e73df75a73/ECAM2015-706782.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/a33187840533/ECAM2015-706782.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/7c7dee704ca8/ECAM2015-706782.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/4633af9a7fdb/ECAM2015-706782.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/cb2db1d321c9/ECAM2015-706782.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e749/4691623/b975da3df18c/ECAM2015-706782.009.jpg

相似文献

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The Preventive Effect on Ethanol-Induced Gastric Lesions of the Medicinal Plant Plumeria rubra: Involvement of the Latex Proteins in the NO/cGMP/K ATP Signaling Pathway.

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引用本文的文献

[1]
Protective effect of proteins extracted from Plumeria pudica latex on ethanol-induced gastric injury in mice.

Acta Cir Bras. 2025-6-6

[2]
Purification, Partial Characterization, and Evaluation of the Antiulcer Activity of Leaf Lectin.

Protein Pept Lett. 2022

[3]
Traditional Herbal Medicine in Mesoamerica: Toward Its Evidence Base for Improving Universal Health Coverage.

Front Pharmacol. 2020-7-31

本文引用的文献

[1]
Antiedematogenic and antioxidant properties of high molecular weight protein sub-fraction of Calotropis procera latex in rat.

J Basic Clin Pharm. 2015-3

[2]
Role of soluble guanylate cyclase activation in the gastroprotective effect of the HO-1/CO pathway against alendronate-induced gastric damage in rats.

Eur J Pharmacol. 2012-12-21

[3]
Antioxidant action of mangrove polyphenols against gastric damage induced by absolute ethanol and ischemia-reperfusion in the rat.

ScientificWorldJournal. 2012

[4]
Effects of hecogenin and its possible mechanism of action on experimental models of gastric ulcer in mice.

Eur J Pharmacol. 2012-3-8

[5]
Investigations on gastroprotective effect of citalopram, an antidepressant drug against stress and pyloric ligation induced ulcers.

Pharmacol Rep. 2011

[6]
Gastroprotective potential of frutalin, a D-galactose binding lectin, against ethanol-induced gastric lesions.

Fitoterapia. 2012-1-21

[7]
Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models.

J Ethnopharmacol. 2011-6-22

[8]
Antitumor effect of laticifer proteins of Himatanthus drasticus (Mart.) Plumel - Apocynaceae.

J Ethnopharmacol. 2011-6-6

[9]
[Proton pump inhibitors and infection risk].

Rev Esp Quimioter. 2011-3

[10]
Carbenoxolone gastroprotective mechanism: participation of nitric oxide/(c) GMP/K(ATP) pathway in ethanol-induced gastric injury in the rat.

Fundam Clin Pharmacol. 2010-11-24

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