Gaynes Bradley N, Rush A John, Trivedi Madhukar H, Wisniewski Stephen R, Spencer Donald, Fava Maurizio
Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill 27599, USA.
Cleve Clin J Med. 2008 Jan;75(1):57-66. doi: 10.3949/ccjm.75.1.57.
The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut "winner", it does provide guidance on how to start therapy and how to proceed if initial treatment fails.