亚磷酸酯配体的固相平行合成
Solid-phase parallel synthesis of phosphite ligands.
作者信息
Swennenhuis Bert H G, Chen Ruifang, van Leeuwen Piet W N M, de Vries Johannes G, Kamer Paul C J
机构信息
Van 't Hoff Institute of Molecular Sciences, University of Amsterdam, The Netherlands.
出版信息
Org Lett. 2008 Mar 6;10(5):989-92. doi: 10.1021/ol703070x. Epub 2008 Feb 1.
Various routes for the synthesis of polymer-bound phosphites and phosphoramidites have been investigated. In the presence of a suitable activator the supported phosphoramidites react cleanly with alcohols to give the corresponding monodentate phosphite ligands in solution. We have applied this novel solid-phase route in the parallel synthesis of several monodentate chiral and achiral phosphite ligands.
人们已经研究了合成聚合物负载亚磷酸酯和亚磷酰胺的各种途径。在合适的活化剂存在下，负载的亚磷酰胺与醇类发生完全反应，在溶液中生成相应的单齿亚磷酸酯配体。我们已将这种新型的固相合成途径应用于几种单齿手性和非手性亚磷酸酯配体的平行合成中。
Zotero 插件