新型、可调谐、高效手性双二氢苯并氧杂磷杂环戊烯配体用于不对称氢化反应。
Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation.
机构信息
Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, Connecticut 06877, USA.
出版信息
Org Lett. 2010 Jan 1;12(1):176-9. doi: 10.1021/ol9025815.
PMID:19950894
Abstract
A series of novel, efficient, air-stable, and tunable chiral bisdihydrobenzooxaphosphole ligands (BIBOPs) were developed for rhodium-catalyzed hydrogenations of various functionalized olefins such as alpha-arylenamides, alpha-(acylamino)acrylic acid derivatives, beta-(acylamino)acrylates, and dimethyl itaconate with excellent enantioselectivities (up to 99% ee) and reactivities (up to 2000 TON).
摘要
一系列新型、高效、空气稳定且可调节的手性双二氢苯并氧杂磷杂环戊烯配体（BIBOPs）被开发出来，用于铑催化的各种官能化烯烃的氢化反应，如α-芳烯酰胺、α-（酰氨基）丙烯酸衍生物、β-（酰氨基）丙烯酸酯和二甲基马来酸二甲酯，具有优异的对映选择性（高达 99%ee）和反应活性（高达 2000TON）。
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