糖基硫代亚胺酯在固相寡糖合成中的应用。

Application of glycosyl thioimidates in solid-phase oligosaccharide synthesis.

作者信息

Parlato M Cristina, Kamat Medha N, Wang Haisheng, Stine Keith J, Demchenko Alexei V

机构信息

Department of Chemistry and Biochemistry, University of Missouri-St. Louis, One University Boulevard, St. Louis, Missouri 63121, USA.

出版信息

J Org Chem. 2008 Mar 7;73(5):1716-25. doi: 10.1021/jo701902f. Epub 2008 Feb 1.

DOI:10.1021/jo701902f

PMID:18237185

Abstract

Two stable classes of thioimidoyl derivatives, S-benzoxazolyl (SBox) and S-thiazolinyl (STaz) glycosides, were investigated as glycosyl donors for solid-phase oligosaccharide synthesis. It was demonstrated that these derivatives are suitable for both glycosyl acceptor-bound and glycosyl donor-bound strategies, commonly employed in resin-supported oligosaccharide synthesis.

摘要

研究了两类稳定的硫亚氨基衍生物，即S-苯并恶唑基（SBox）和S-噻唑啉基（STaz）糖苷，作为固相寡糖合成的糖基供体。结果表明，这些衍生物适用于树脂支持的寡糖合成中常用的糖基受体结合和糖基供体结合策略。