Maroun Lisa Leth, Graem Niels, Skibsted Lillian
Department of Pathology, The Centre of Diagnostic Investigations, Rigshospitalet, Copenhagen University Hospital, Denmark.
Pediatr Dev Pathol. 2008 Jan-Feb;11(1):59-62. doi: 10.2350/07-04-0261.1.
Two early-2nd-trimester fetuses were aborted as a result of nuchal edema and suspected severe heart malformation. At autopsy one fetus demonstrated nuchal edema, mild hydronephrosis, and cor triatriatum dexter associated with ventricular septal defect and tubular hypoplasia of the aortic arch. The other fetus demonstrated severe nuchal edema, and cor triatriatum dexter was the only malformation. Cor triatriatum dexter is a rare cardiac malformation characterized by division of the right atrium into 2 compartments by a usually fenestrated membrane representing remnants of the right valve of the embryonic sinus venosus. This malformation has been diagnosed in adults and children by echocardiography, surgery, or autopsy but has not previously been published in fetuses.
两名孕中期早期胎儿因颈部水肿和疑似严重心脏畸形而流产。尸检时，一名胎儿表现为颈部水肿、轻度肾积水以及与室间隔缺损和主动脉弓管状发育不全相关的右房三房心。另一名胎儿表现为严重颈部水肿，且右房三房心是唯一的畸形。右房三房心是一种罕见的心脏畸形，其特征是右心房被一层通常有小孔的膜分隔成两个腔室，该膜代表胚胎静脉窦右瓣的残余。这种畸形已通过超声心动图、手术或尸检在成人和儿童中得到诊断，但此前尚未在胎儿中报道过。
