Warr E, Das S, Dong Y, Dimopoulos G
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205-2179, USA.
Insect Mol Biol. 2008 Feb;17(1):39-51. doi: 10.1111/j.1365-2583.2008.00778.x.
Gram-negative bacteria-binding proteins (GNBPs) are pattern recognition receptors which contribute to the defensive response against Plasmodium infection in Anopheles. We have characterized the GNBP gene family in Anopheles gambiae at the molecular level, and show that they are functionally diverse components of the A. gambiae innate immune system. GNBPB4 is a major factor in the defence against a broad range of pathogens, while the other GNBPs have narrower defence specificities. GNBPB4 is associated with the regulation of immune signalling pathways and was found to interact with the Gram-negative Escherichia coli and weakly co-localized with Plasmodium berghei ookinetes in the mosquito midgut epithelium.
革兰氏阴性菌结合蛋白（GNBPs）是模式识别受体，有助于按蚊对疟原虫感染作出防御反应。我们在分子水平上对冈比亚按蚊中的GNBP基因家族进行了表征，结果表明它们是冈比亚按蚊先天免疫系统中功能多样的组成部分。GNBPB4是抵御多种病原体的主要因素，而其他GNBPs的防御特异性较窄。GNBPB4与免疫信号通路的调节有关，并且被发现与革兰氏阴性大肠杆菌相互作用，并在蚊子中肠上皮细胞中与伯氏疟原虫动合子弱共定位。
