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Temperature-sensitive mutants of Balb/3T3 cells: description of a mutant affected in cellular and polyoma virus DNA synthesis.

作者信息

Slater M L, Ozer H L

出版信息

Cell. 1976 Feb;7(2):289-95. doi: 10.1016/0092-8674(76)90028-3.

DOI:10.1016/0092-8674(76)90028-3
PMID:182373
Abstract

A temperature-sensitive Dna- mutant (ts-2) of the mouse cell Balb/3T3 is characterized. Studies with synchronized cells indicate that the defect is in DNA synthesis itself, rather than in progress toward its initiation. ts-2 supports polyoma DNA synthesis after infection at 33degreesC but not at 38degreesC. Viral DNA synthesis begun at 33degreesC is inhibited upon shift to 38degreesC. A procedure is proposed by which viral DNA synthesis can be used to distinguish different classes of cell Dna- mutants.

摘要

相似文献

1
Temperature-sensitive mutants of Balb/3T3 cells: description of a mutant affected in cellular and polyoma virus DNA synthesis.
Cell. 1976 Feb;7(2):289-95. doi: 10.1016/0092-8674(76)90028-3.
2
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4
In vitro polyoma DNA synthesis: studies on an early temperature-sensitive mutant.体外多瘤病毒DNA合成：对一种早期温度敏感突变体的研究。
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Induction of virus multiplication in 3T3 cells transformed by a thermosensitive mutant of polyoma virus. II. Formation of oligometric polyoma DNA molecules.多瘤病毒温度敏感突变体转化的3T3细胞中病毒增殖的诱导。II. 寡聚多瘤病毒DNA分子的形成。
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6
In vitro polyoma DNA synthesis: characterization of a system from infected 3T3 cells.体外多瘤病毒DNA合成：来自感染的3T3细胞的系统的特性
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An investigation of factors influencing the susceptibility of Balb-c 3T3 cells to polyoma virus.影响Balb-c 3T3细胞对多瘤病毒易感性的因素研究。
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8
BALB/3T3 cells infected by the ts3 mutant of polyoma virus fail to accumulate virus-specific early RNA at the nonpermissive temperature.被多瘤病毒ts3突变体感染的BALB/3T3细胞在非允许温度下无法积累病毒特异性早期RNA。
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Mouse polyoma virus and adenovirus replication in mouse cells temperature-sensitive in DNA synthesis.
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Characterization of a temperature-sensitive mutant of BALB-c 3T3 cells.
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