Cramer Joyce A, Roy Anuja, Burrell Anita, Fairchild Carol J, Fuldeore Mahesh J, Ollendorf Daniel A, Wong Peter K
Yale University School of Medicine, New Haven, CT, USA.
Value Health. 2008 Jan-Feb;11(1):44-7. doi: 10.1111/j.1524-4733.2007.00213.x.
The aim of the study is to provide guidance regarding the meaning and use of the terms "compliance" and "persistence" as they relate to the study of medication use.
A literature review and debate on appropriate terminology and definitions were carried out.
Medication compliance and medication persistence are two different constructs. Medication compliance (synonym: adherence) refers to the degree or extent of conformity to the recommendations about day-to-day treatment by the provider with respect to the timing, dosage, and frequency. It may be defined as "the extent to which a patient acts in accordance with the prescribed interval, and dose of a dosing regimen." Medication persistence refers to the act of continuing the treatment for the prescribed duration. It may be defined as "the duration of time from initiation to discontinuation of therapy." No overarching term combines these two distinct constructs.
Providing specific definitions for compliance and persistence is important for sound quantitative expressions of patients' drug dosing histories and their explanatory power for clinical and economic events. Adoption of these definitions by health outcomes researchers will provide a consistent framework and lexicon for research.
本研究旨在就“依从性”和“持续性”这两个术语在药物使用研究中的含义及应用提供指导。
开展了关于恰当术语和定义的文献综述及讨论。
药物依从性和药物持续性是两个不同的概念。药物依从性（同义词：坚持）是指患者在治疗时间、剂量和频次方面遵循医护人员日常治疗建议的程度。它可被定义为“患者按照规定的间隔和剂量方案服药的程度”。药物持续性是指持续进行规定疗程治疗的行为。它可被定义为“从开始治疗到停止治疗的持续时间”。没有一个总括性术语能涵盖这两个不同的概念。
为依从性和持续性提供具体定义，对于准确量化患者的用药史及其对临床和经济事件的解释力很重要。健康结果研究人员采用这些定义将为研究提供一个一致的框架和词汇表。
