Pregnancy-induced hemolytic anemia with a possible immune-related mechanism.
作者信息
Katsuragi Shinji, Sameshima Hiroshi, Omine Mitsuhiro, Ikenoue Tsuyomu
机构信息
Department of Obstetrics and Gynecology, Miyazaki Medical College, University of Miyazaki, Kiyotake-Cho, Miyazaki, Japan.
出版信息
Obstet Gynecol. 2008 Feb;111(2 Pt 2):528-9. doi: 10.1097/01.AOG.0000287292.74846.f2.
BACKGROUND
Pregnancy-induced hemolytic anemia is a rare maternal complication that occurs during pregnancy and resolves soon after delivery. The mechanism is unclear, and the disease is often referred to as unexplained hemolytic anemia associated with pregnancy.
CASE
We report a case of life-threatening hemolytic anemia that occurred during pregnancy and resolved spontaneously soon after delivery. Direct and indirect Coombs test results were negative. Several possible causes were investigated, but all were ruled out. However, an increased immunoglobulin G level was observed in maternal red blood cells throughout pregnancy when the patient was severely anemic. The immunoglobulin G level decreased after delivery and was close to the control level on postpartum day 5.
CONCLUSION
These observations suggest that the hemolytic anemia in this patient had an immune-related etiology.
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